超声联合免疫组织化学指标预测新辅助化疗后乳腺癌转移性腋窝淋巴结病理完全缓解

目的 观察超声联合免疫组织化学指标预测新辅助化疗(NACT)后乳腺癌转移性腋窝淋巴结病理完全缓解(pCR)的价值.方法 纳入155例接受NACT的乳腺癌伴腋窝淋巴结转移患者,根据腋窝淋巴结清扫(ALND)术后病理结果将其分为pCR组(n=59)及非pCR组(n=96);比较2组NACT前免疫组织化学指标及乳腺癌病灶及腋...

Ultrasound combined with immunohistochemical indexes for predicting pathological complete response of metastatic axillary lymph nodes of breast cancer after neoadjuvant chemotherapy

Objective To observe the value of ultrasound combined with immunohistochemical indexes for predicting pathological complete response (pCR) of metastatic axillary lymph nodes of breast cancer after neoadjuvant chemotherapy (NACT). Methods Totally 155 breast cancer patients with axillary lymph node metastasis who then underwent NACT were enrolled and divided into pCR group (n=59) and non-pCR group (n=96) according to the pathological results after axillary lymph node dissection (ALND). The immunohistochemical indexes and ultrasonic characteristics of primary breast cancer and metastatic axillary lymph nodes before NACT were compared between groups. Then logistic prediction model was established, and its value for predicting metastatic axillary lymph node pCR after NACT was observed. Results There were significant differences of Ki-67, human epidermal growth factor receptor-2 (HER-2) of primary breast cancer, as well as the short diameter, the maximum cortical thickness and the morphologies of metastatic axillary lymph nodes between groups (all P<0.05). The area under the curve (AUC), the sensitivity and specificity of logistic prediction model for predicting pCR of metastatic axillary lymph nodes after NACT were 0.734, 42.37% (25/59) and 84.38% (81/96), respectively. Conclusion Ultrasound combined with immunohistochemistry before NACT had certain value for predicting pCR of metastatic axillary lymph nodes of breast cancer after NACT.