Long time exposure to soy/isoflavone-rich diet enhances testicular and prostate health in Long-Evans rats

Soy isoflavone consumption appears to be beneficial for several health parameters. We report the influence of (lifelong exposure to) a high soy/isoflavone (High-Iso) compared to a low soy/isoflavone (Low-Iso) diet on body weight (BW), white adipose tissue (WAT) deposition, prostate weight (PW), testicular weight (TW), and testosterone levels in young adult male Long-Evans rats. WAT deposition and the WAT/BW ratios were significantly less in High-Iso vs. the Low-Iso fed animals. TW and TW/BW ratios were significantly greater in High-Iso vs. Low-Iso fed animals. Sertoli cell area, seminiferous tubule lumens and seminiferous tubule areas were significantly greater in High-Iso vs. Low-Iso animals. These data suggest that consumption of a soy diet high in isoflavone/polyphenolic molecules from conception appear to be beneficial in decreasing PW and WAT deposition while increasing TW, Sertoli cell area and seminiferous tubule volume.