GUD1 (YDL238c) encodes Saccharomyces cerevisiae guanine deaminase, an enzyme expressed during post-diauxic growth |
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Authors: | Saint-Marc Christelle Daignan-Fornier Bertrand |
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Affiliation: | Institut de Biochimie et Génétique Cellulaires, Université Bordeaux 2 CNRS UMR 5095, 33077 Bordeaux Cedex, France. |
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Abstract: | Purine salvage is a complex pathway allowing a correct balance between adenylic and guanylic derivatives. In this paper, we show that GUD1 (YDL238c) encodes guanine deaminase, a catabolic enzyme producing xanthine and ammonia from guanine. Importantly, Gud1p activity was higher during post-diauxic growth, suggesting that a decrease of the guanylic nucleotide pool could be required when cells shift from proliferation to quiescence. |
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Keywords: | purine salvage guanine catabolism post‐diauxic xanthine |
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