Combined chemo/photothermal therapy based on mesoporous silica-Au core-shell nanoparticles for hepatocellular carcinoma treatment |
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| Authors: | Jian Wang Yamin Zhang Lei Liu Zilin Cui Xiaolong Liu Lianjiang Wang |
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| Affiliation: | 1. Department of Hepatobiliary Surgery, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin, PR China;2. Hepatobiliary Surgery Department, Tianjin First Center Hospital, The First Central Clinical College of Tianjin Medical University, Tianjin Clinical Research Center for Organ Transplantation, Key Laboratory for Critical Care Medicine of the Ministry of Health, Tianjin, PR China;3. Hepatobiliary Surgery Department, Tianjin First Center Hospital, Tianjin Clinical Research Center for Organ Transplantation, Key Laboratory for Critical Care Medicine of the Ministry of Health, Tianjin, PR China;4. Department of Transplantation Center, Tianjin First Center Hospital, Tianjin Clinical Research Center for Organ Transplantation, Key Laboratory for Critical Care Medicine of the Ministry of Health, Tianjin, PR China |
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| Abstract: | Chemotherapy has been widely used for treatment to malignant cancer, such as hepatocellular carcinoma (HCC). Chemotherapeutic effect was not often efficient to achieve totally tumor ablation due to the poor cellular uptake and drug resistance. To address these problems, a novel nanoplatform was constructed based on nontoxic mesoporous silica nanoparticles (MSNs) for a combined chemo/photothermal therapy to enhance tumor cell accumulation and promote toxicity of chemotherapeutic drugs. Prepared MSNs were consisted of Au nanoshell for photothermal conversion and a first-line anti-HCC drug-sorafenib (SO) for chemotherapy. The SO-Au-MSNs could help SO accumulate more in hepatic cancer cells. Under near infrared irradiation, SO-Au-MSNs exerted a high cell inhibition rate which could be attributed to the enhanced toxicity of SO under hyperthermia and synergistic chemo/photothermal therapy. SO-Au-MSNs showed a good compatibility as well as efficient cell cytotoxicity. Overall, SO-Au-MSNs would be a promising candidate for further enhancing the antitumor effect on HCC. |
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| Keywords: | Chemotherapy photothermal therapy mesoporous silica nanoparticles Au nanoshell sorafenib |
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