Thermodynamic solubility and solvation behavior of ferulic acid in different (PEG-400 + water) binary solvent mixtures |
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Authors: | Faiyaz Shakeel Nazrul Haq Nasir A. Siddiqui |
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Affiliation: | 1. Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia;2. faiyazs@fastmail.fm;4. Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia |
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Abstract: | This work was carried out to determine solubility, solution thermodynamics, solvation behavior, and molecular interactions of a natural compound ferulic acid (FLA) in different ‘[polyethylene glycol-400 (PEG-400) + water]’ binary solvent mixtures at ‘T?=?298.2 K to 318.2?K’ and ‘p?=?0.1?MPa.’ The mole fraction solubilities (xe) of FLA were determined by liquid chromatographic technique using a static equilibrium technique. The obtained solubility data of FLA were regressed using ‘Van’t Hoff, Apelblat, Yalkowsky-Roseman and Jouyban-Acree models.’ The solubility of FLA (expressed in mole fraction) was enhanced with elevation in absolute temperature in each ‘PEG-400?+?water’ binary solvent mixture evaluated. The maximum xe values of FLA were recorded in neat PEG-400 (1.94?×?10?1) at ‘T?=?318.2 K.’ While, the minimum one was obtained in neat water (4.90?×?10?5) at ‘T?=?298.2 K.’ The molecular interactions between FLA-PEG-400 and FLA-water were obtained by determination of activity coefficients of FLA in different ‘PEG-400?+?water’ binary solvent mixtures. The physical data of activity coefficients recorded in this work suggested strong molecular interactions in FLA-PEG-400 in comparison with FLA-water. ‘Apparent thermodynamic analysis’ suggested an ‘endothermic and entropy-driven dissolution’ of FLA in each ‘PEG-400?+?water’ binary solvent mixture investigated. |
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Keywords: | Activity coefficient correlation ferulic acid polyethylene glycol-400 thermodynamics solubility |
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