| 番茄水提取物对动脉粥样硬化大鼠的影响 |
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| 引用本文： | 吴建璋,李赐玉,刘金磊,卢凤来,陈月圆,李典鹏.番茄水提取物对动脉粥样硬化大鼠的影响[J].食品研究与开发,2011,32(11):131-134. |
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| 作者姓名： | 吴建璋 李赐玉 刘金磊 卢凤来 陈月圆 李典鹏 |
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| 作者单位： | 1. 广西壮族自治区中国科学院广西植物研究所,广西桂林541006;广西师范大学,广西桂林541004
2. 广西壮族自治区中国科学院广西植物研究所,广西桂林,541006 |
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| 基金项目： | 广西科学基金应用基础研究专项资助项目(桂科基0991020); 桂林市科学与技术开发项目(20100103-3) |
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| 摘 要： | 研究番茄水提取物(AEL)对高脂诱导动脉粥样硬化(AS)大鼠的影响及可能作用机制。采用高脂饲料喂饲和腹腔注射VD3建立大鼠AS模型2。4周后处死大鼠,检测血清血脂、抗氧化水平及全血黏度,观察主动脉作病理学变化。结果显示AEL给药组明显降低总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)和丙二醛(MDA)含量,明显升高高密度脂蛋白胆固醇(HDL-C)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、一氧化氮(NO)水平,明显降低动脉硬化指数(AI)及全血黏度,不同程度减缓主动脉粥样斑块的形成。AEL具有减缓大鼠动脉粥样硬化形成的作用,其可能与降低TC、TG、LDL-C及全血黏度,提高HDL-C水平及抗氧化有关。
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| 关 键 词： | 番茄 动脉粥样硬化 全血黏度 主动脉 抗氧化 |
Effects of Aqueous Extract of Lycopersicon Esculentum on Atherosclerosis in Rats |
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| WU Jian-zhang,LI Ci-yu,LIU Jin-lei,LU Feng-lai,CHEN Yue-yuan,LI Dian-peng.Effects of Aqueous Extract of Lycopersicon Esculentum on Atherosclerosis in Rats[J].Food Research and Developent,2011,32(11):131-134. |
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| Authors: | WU Jian-zhang LI Ci-yu LIU Jin-lei LU Feng-lai CHEN Yue-yuan LI Dian-peng |
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| Affiliation: | WU Jian-zhang1,LI Ci-yu1,2,LIU Jin-lei1,LU Feng-lai1,CHEN Yue-yuan1,LI Dian-peng1,(1.Guangxi Institute of Botany,Guangxi Zhuangzu Autonomous Region and Chinese Academy of Science,Guilin 541006,Guangxi,China,2.Guangxi Normal University,Guilin 541004,China) |
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| Abstract: | To evaluate the effect and possible mechanism of aqueous extract of Lycopersicon esculentum(AEL) on rats with high-fat induced atherosclerosis.Atherosclerotic rat model was established by feeding high-fat diet and intraperitoneal injection of vitamin D3.Rats were sacrificed 24 weeks later,the levels of serum lipid,anti-oxidation and whole blood viscosity were examined,aortic pathology changes were observed.The levels of TC,TG,LDL-C and MDA in the sera,AI,whole blood viscosity of rats given with AEL were dec... |
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| Keywords: | Lycopersicon esculentum Mill atherosclerosis whole blood viscosity aorta anti-oxidation |
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