光热/pH响应B-CuS-DOX纳米药物用于化疗-光热协同治疗肿瘤

基于纳米材料的化疗-光热协同治疗是一种高效的肿瘤治疗方式, 但如何构建具有高载药量与良好光热转换性能的纳米药物依然面临挑战。本研究通过超声剥离法制备二维硼(boron, B)纳米片, 进一步在其表面原位负载超小粒径硫化铜(CuS)纳米颗粒和化疗药阿霉素(DOX), 形成B-CuS-DOX纳米药物。B-CuS具有高的DOX药物装载能力(864 mg/g)和优异的光热转化性能(在808 nm处的光热转换效率为55.8%), 同时可实现pH及近红外激光双重刺激响应而释放药物。细胞实验表明在808 nm近红外光的照射下, B-CuS-DOX展示了良好的化疗-光热协同治疗效果。本研究构建的纳米药物有望为体内肿瘤治疗提供一种有效的化疗-光热协同治疗策略。

Photothermal/pH Responsive B-CuS-DOX Nanodrug for Chemo-photothermal Synergistic Therapy of Tumor

Nanoparticles-based drug delivery system for synergetic chemo-photothermal therapy is an efficient strategy for tumor therapy.However,construction of nanodrugs with high drug loading capacity and good photothermal conversion property is still a great challenge.In this work,two-dimensional boron nanosheets were prepared by ultrasonic liquid exfoliation method,which were further loaded with ultra-small copper sulfide(CuS)nanoparticles and doxorubicin(DOX)to obtain B-CuS-DOX nanocomposites.The prepared B-CuS-DOX exhibited high drug loading capacity(864 mg/g)and excellent photothermal conversion efficiency(55.8%).In addition,B-CuS-DOX exhibited pH and laser--responsive drug release behavior.In vitro results demonstrated that the prepared B-CuS-DOX achieved a good synergistic effect of chemotherapy and photothermal therapy.This work is expected to provide an effective chemo-photothermal synergistic therapy strategy for tumor therapy.