| (R)-1,1'-联萘-2,2'-二甲酸的合成 |
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| 引用本文： | 严罗一.(R)-1,1'-联萘-2,2'-二甲酸的合成[J].安徽化工,2012,38(3):26-28. |
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| 作者姓名： | 严罗一 |
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| 作者单位： | 武汉理工大学化学工程学院,湖北武汉,430070 |
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| 摘 要： | 研究了(R)-1,1’-联萘-2,2’-二甲酸的合成方法,设计了一条合适的合成路线并进行了优化。以(R)-联二萘酚为起始原料,依次经过羟基的三氟甲基磺酸化反应、甲基化反应、溴代反应、水解反应,最后氧化成(R)-1,1’-联萘-2,2’-二甲酸。在相关文献和专利的基础上,进行了创新,合成路线简单易行,具有应用价值。
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| 关 键 词： | (R)-1 1’-联萘-2 2’-二甲酸 联二萘酚 联萘二甲酸 手性 |
Synthesis of (R)-1, 1'-Binaphthyl-2,2'-DicarBoxylic Acid |
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| YAN Luo-yi.Synthesis of (R)-1, 1'-Binaphthyl-2,2'-DicarBoxylic Acid[J].Anhui Chemical Industry,2012,38(3):26-28. |
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| Authors: | YAN Luo-yi |
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| Affiliation: | YAN Luo-yi(College of Chemical Engineering,Wuhan University of Technology,Wuhan 430070,China) |
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| Abstract: | A simple synthetic approach to(R)-1,1’-Binaphthyl-2,2’-DicarBoxylic Acid has been discussed in this essay.A good synthetic route has been designed and optimized.The starting material is(R)-binaphthol,which finally affords(R)-1,1’-Binaphthyl-2,2’-DicarBoxylic Acid via Trifluoromethyl Sulfonation,Methylation,Bromination,Hydrolysis and Oxidation,successively.On the basis of the literature and patents,we invent the novel synthetic route,which is simple and applicable. |
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| Keywords: | (R)-1 1’-Binaphthyl-2 2’-DicarBoxylic Acid Binaphthol Binaphthyl dicarboxylic acid Chiral |
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