| 3-氨基-4-氰基吡唑的合成 |
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| 引用本文： | 王春,徐自奥.3-氨基-4-氰基吡唑的合成[J].安徽化工,2012,38(3):14-15. |
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| 作者姓名： | 王春 徐自奥 |
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| 作者单位： | 安徽省化工研究院,安徽合肥,230041;安徽省新星药物开发有限责任公司,安徽合肥,230088 |
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| 摘 要： | 以丙二腈为起始原料,与苯胺缩合后环化,两步反应制得3-氨基-4-氰基吡唑,产品纯度达到99.2%,反应总收率73.6%,工艺操作简单,适于工业化生产。
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| 关 键 词： | 3-氨基-4-氰基吡唑 合成 中间体 |
Synthesis of 3-Aminopyrazole-4-carbonitrile |
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| WANG Chun
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XU Zi-Ao.Synthesis of 3-Aminopyrazole-4-carbonitrile[J].Anhui Chemical Industry,2012,38(3):14-15. |
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| Authors: | WANG Chun XU Zi-Ao |
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| Affiliation: | 1. Anhui Research Institute of Chemical Industry, Hefei 230041, China; 2. Anhui New Star Pharmaceutical Development Co. Ltd., Hefei 230088, China) |
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| Abstract: | 3-Amniopyrazole-4-carbonitrile was synthesized from malononitrile, condensation with aniline and cyclization in an overall yield of 73.8%, the purity of the product reached 99.2%. The process was simple and suitable for scale-up production. |
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| Keywords: | 3-aminopyrazole-4-carbonitrile synthesis intermediate |
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