| 催化不对称烷基化反应中氨基醇配体研究进展 |
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| 引用本文： | 秦泉,宋庆宝. 催化不对称烷基化反应中氨基醇配体研究进展[J]. 广州化工, 2009, 37(2): 54-57 |
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| 作者姓名： | 秦泉 宋庆宝 |
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| 作者单位： | 浙江工业大学化学工程与材料学院,浙江,杭州,310032;浙江工业大学化学工程与材料学院,浙江,杭州,310032 |
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| 摘 要： | 二烷基锌对醛的不对称加成反应是合成手性二级醇的有效方法，反应产物手性二级醇是药物、精细化学品、天然产物的重要中间体，手性氨基醇是诱导这类反应手性配体的重要组成部分并且表现出了很高的对映选择性。综述了催化该类反应手性氨基醇配体的一些研究新进展。
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| 关 键 词： | 手性氨基醇 不对称催化 二乙基锌 |
Progress of Amino Alcohol Ligands in Asymmetric Catalytic Alkylation |
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| QIN Quan,SONG Qing-bao. Progress of Amino Alcohol Ligands in Asymmetric Catalytic Alkylation[J]. GuangZhou Chemical Industry and Technology, 2009, 37(2): 54-57 |
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| Authors: | QIN Quan SONG Qing-bao |
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| Affiliation: | College of Chemical Engineering and Materials Science;Zhejiang University of Technology;Zhejiang Hangzhou 310032;China |
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| Abstract: | Asymmetric addition of dialkyzinc to aldehyde was a successful method for synthesis of chiral secondary alcohols,which were valuable buildings blocks for pharmaceuticals,fine chemicals and natural products.The ligand of chiral amino alcohol constituted an important part of the chiral ligands induced the asymmetric addition reaction and performed high enantioselectivity.In this paper,the application of chiral amino alcohols on asymmetric catalytic addition reaction of diethylzinc to aldehyde was summarized. |
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| Keywords: | chiral amino alcohol asymmetric catalysis diethylzinc |
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