| 3,4-亚甲二氧基苯乙酮过氧酸氧化法合成芝麻酚 |
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| 引用本文： | 朱兆富,沈喜海,胡永利,张志刚. 3,4-亚甲二氧基苯乙酮过氧酸氧化法合成芝麻酚[J]. 精细化工, 2002, 19(11): 667-668,671 |
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| 作者姓名： | 朱兆富 沈喜海 胡永利 张志刚 |
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| 作者单位： | 河北职业技术师范学院,化学系,河北,昌黎,066600 |
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| 摘 要： | 3,4 亚甲二氧基苯乙酮 ,用过氧乙酸氧化生成乙酸 3,4 亚甲二氧基苯酚酯 ,此酯直接水解即获得产率 87 7%的芝麻酚 (3,4 亚甲二氧基苯酚 )。适宜的氧化条件 :n(过氧乙酸 )∶n(3,4 亚甲二氧基苯乙酮 ) =(1 0 5～ 1 15 )∶1,2 0～ 30℃反应 4h ,少量锌粉脱色 ;适宜的水解条件 :w(NaOH) =5 %水溶液室温反应 4h。
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| 关 键 词： | 芝麻酚 3,4-亚甲二氧基苯乙酮 过氧乙酸 Baeyer-Villiger氧化反应 |
| 文章编号： | 1003-5214(2002)11-0667-03 |
Synthesis of 3,4-Methylenedioxyphenol by Acetylhydroperoxide Oxidation Method |
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| ZHU Zhao fu,SHEN Xi hai,HU Yong li,ZHANG Zhi gang. Synthesis of 3,4-Methylenedioxyphenol by Acetylhydroperoxide Oxidation Method[J]. Fine Chemicals, 2002, 19(11): 667-668,671 |
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| Authors: | ZHU Zhao fu SHEN Xi hai HU Yong li ZHANG Zhi gang |
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| Abstract: | 3,4-Methylenedioxyphenol(Ⅰ)was prepared from 3,4 methylenedioxyacetophenone(Ⅱ)by oxidation with acetylhydroperoxide and hydrolysis.Effects of reaction conditions on yield and quality of the product were investigated. The optimum conditions of oxidation were n (CH 3COOH)∶ n (Ⅱ)=(1 05-1 15)∶1,reaction temperature 20-30 ℃ and reaction time 4 h.The crude acetic ester of Ⅰ was directly hydrolyzed with w (NaOH)=5% aqueous solution at room temperature for 4 h to give pure Ⅰ in 87 7% yield. |
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| Keywords: | 3 4 -methylenedioxyphenol 3 4 methylenedioxyacetophenone acetylhydroperoxide Baeyer Villiger oxidation |
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