Temperature-dependent transparency of poly(HPMA-co-DMA) hydrogels: effect of synthesis parameters |
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Authors: | Man-Hee HanJung-Whan Kim Jinwon KimJung Yoon Ko Jules J MagdaIn Suk Han |
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Affiliation: | a M-Biotech Inc., 2411 South 1070 West, Suite C, Salt Lake City, UT 84119, USA b Department of Chemical and Fuels Engineering, University of Utah, 50 South Central Campus Drive, Room 3290, Salt Lake City, UT 84112, USA |
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Abstract: | The acrylic comonomers hydroxypropyl methacrylate (HPMA) and N,N-dimethylaminoethyl methacrylate (DMA) have been used in several earlier studies to produce pH-responsive hydrogels. However, these same monomers can also be used to prepare hydrogels that are highly responsive to temperature. One manifestation of this temperature sensitivity is a sharp decrease in hydrogel optical transparency that occurs when the temperature exceeds a critical transition value. For example, a hydrogel that exhibits a swelling transition at the physiological pH value of 7.4 has a transition temperature of about 45 °C when the environmental salt concentration is 0.15 M. The value of the transparency transition temperature is shown to depend on hydrogel synthesis parameters such as comonomer mole ratio, crosslinker mole ratio, and even initiator concentration. By reducing the mole ratio of the crosslinker tetraethylene glycol dimethacrylate (TEGDMA), the transition temperature can be lowered by as much as 15 °C. Environmental salt concentration and solvent polarity are also shown to influence the transition temperature. |
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Keywords: | Lower critical solution temperature Thermo-responsive hydrogel Hydrophobic interaction |
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