| 羟基磷灰石微纳结构对蛋白吸附的影响 |
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| 引用本文： | 付亚康,周 雪,肖东琴,匙 峰,卢晓英,翁 杰.羟基磷灰石微纳结构对蛋白吸附的影响[J].无机材料学报,2015,30(5):523-528. |
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| 作者姓名： | 付亚康 周 雪 肖东琴 匙 峰 卢晓英 翁 杰 |
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| 作者单位： | (1. 西南交通大学 材料先进技术教育部重点实验室, 成都 610031; 2. 雅安职业技术学院, 雅安 625000) |
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| 基金项目： | 国家重点基础研究发展计划(2012CB933600); 国家自然科学基金(51172188); 四川省科技支撑计划(2010FZ0048); 四川省高校科研创新团队建设计划项目(14TD0050) |
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| 摘 要： | 本研究采用水热反应法, 在不同浓度环己烷六羧酸(H6E)模板调控作用下, 合成了具有不同表面微纳结构的羟基磷灰石(HAP)微粒, 并采用XRD、BET、FTIR和SEM对其进行表征。对HAP微粒进行了牛血清白蛋白(BSA)、纤维蛋白原(FN)和溶菌酶(LYS)的吸附及释放实验。结果表明: H6E能够在HAP微粒表面构建微纳结构, 不同微纳结构对不同蛋白质具有选择性吸附作用; 在H6E浓度为50 mmol/L的合成条件下制备的中空结构HAP微粒(HAP50)其载蛋白后体外释放具有明显的蛋白缓释性能。
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| 关 键 词： | 羟基磷灰石 环己烷六羧酸 微纳结构 蛋白吸附 |
| 收稿时间： | 2014-10-10 |
| 修稿时间： | 2014-11-20 |
Influence of Micro-nano Structure of Haydroxyapatite Particles on Protein Adsorption |
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| FU Ya-Kang,ZHOU Xue,XIAO Dong-Qin,SHI Feng,LU Xiao-Ying,WENG Jie.Influence of Micro-nano Structure of Haydroxyapatite Particles on Protein Adsorption[J].Journal of Inorganic Materials,2015,30(5):523-528. |
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| Authors: | FU Ya-Kang ZHOU Xue XIAO Dong-Qin SHI Feng LU Xiao-Ying WENG Jie |
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| Affiliation: | (1. Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China; 2. Ya’an Vocational College, Ya’an 625000, China) |
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| Abstract: | Hydroxyapatite (HAP) particles were hydrothermally synthesized with the surface morphologies adjusted by cyclohexane-1, 2, 3, 4, 5, 6-hexacarboxylic acid (H6E) as the template. HAP particles were characterized by XRD, BET, SEM and FTIR. The protein adsorption-desorption behaviors of positively charged lysozyme (LYS), fibrinogen (FN) and negatively charged bovine serum albumin (BSA) on these HAP particles were examined. The results indicate that using H6E as a template to fabricate micro-nano structures on HAP particles through hydrothermal reaction is simple and controllable. HAP particles with micro-nano structures show selective protein adsorption-desorption properties for different proteins. The protein-loaded shell-like HAP particle (HAP50-protein) shows an excellent protein release behavior in vitro. |
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| Keywords: | hydroxyapatite H6E micro-nano structure protein adsorption |
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