崂山酸枣芽茶改善小鼠睡眠作用的研究

目的研究崂山酸枣芽茶对小鼠睡眠作用的影响。方法观察崂山酸枣芽茶对小鼠自主活动的影响、对戊巴比妥钠诱导小鼠睡眠时间的影响、对巴比妥钠阈下剂量诱导小鼠睡眠的协同作用以及对苯丙胺诱导小鼠中枢兴奋的拮抗作用。结果崂山酸枣芽茶对小鼠自主活动呈明显抑制作用,同时可以延长戊巴比妥钠诱导的小鼠睡眠时间。与模型对照组比较,低、中、高崂山酸枣芽茶剂量组睡眠时间分别增加了19.4%、63.7%和94.8%;增加巴比妥钠诱导的小鼠睡眠发生率和缩短巴比妥钠诱导的小鼠睡眠潜伏期,与模型对照组比较,低、中、高崂山酸枣芽茶剂量组小鼠睡眠发生率和睡眠潜伏期分别增加和缩短了6.67%、19.97%、39.97%和7.0%、18.2%、41.9%;显著抑制了苯丙胺诱导小鼠的中枢兴奋作用。结论崂山酸枣芽茶能明显的改善睡眠,具有一定的安神、镇静作用。

Improvement of sleep by Laoshan Zizyphus jujube bud tea in mice

Objective To investigate the effect of Laoshan Zizyphus jujube bud tea on improving sleep function in mice. Methods The influence of Laoshan Zizyphus jujube bud tea on autonomic activities of mice were observed, and also the effect of pentobarbital sodium on sleep time in mice. Synergistic effect of subthreshold dose of pentobarbital sodium on sleep and antagonism of amphetamine by inducing central excitation in mice were studied. Results Laoshan Zizyphus jujube bud tea inhibited autonomic activities of mice, and extended the pentobarbital sodium induced sleeping time. Compared with model control group, the sleep time of mice, which were treated by high, medium and low laoshan Zizyphus jujube bud tea dose, increased by 94.8%, 63.7% and 19.4%, respectively. Zizyphus jujube bud tea increased sleeping rate induced by pentobarbital sodium and shortened sleeping latency induced by pentobarbital sodium in mice. Compared with model control group, sleep incidence and sleep latency of high, medium and low Laoshan Zizyphus jujube bud tea dose group increased and shortened by 6.67%, 19.97%, 39.97% and 7.0%, 39.97%, 41.9%, respectively. Laoshan Zizyphus jujube bud tea inhibited central excitation induced by Benzedrine in mice. Conclusion Laoshan Zizyphus jujube bud tea can obviously improve sleep and have a certain sedation function.