| 1-（4-氟苄基）-2-氯-1H-苯并咪唑的合成研究 |
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| 引用本文： | 钟光祥,刘福金,陈路路,胡金清.1-（4-氟苄基）-2-氯-1H-苯并咪唑的合成研究[J].浙江化工,2009,40(2):12-14. |
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| 作者姓名： | 钟光祥 刘福金 陈路路 胡金清 |
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| 作者单位： | 浙江工业大学药学院,浙江,杭州,310032 |
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| 摘 要： | 以邻苯二胺和乙酰乙酸乙酯为起始原料，经环合、N-烷基化、水解、氯化反应制得1-（4-氟苄基）-2-氯-1H-苯并咪唑。考察了投料比对产物收率的影响，经过优化，确定了较佳的工艺条件，总收率为56．4％。产品结构经1^H NMR确认。
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| 关 键 词： | 1-(4-氟苄基)-2-氯-1H-苯并咪唑 咪唑斯汀 中间体 合成 |
Synthesis of 1-(4-Fluorobenzyl)-2-chloro-lH-benzo[d]Imidazole |
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| ZHONG Guang-xiang,LIU Fu-jin,CHEN Lu-lu,HU Jin-qing.Synthesis of 1-(4-Fluorobenzyl)-2-chloro-lH-benzo[d]Imidazole[J].Zhejiang Chemical Industry,2009,40(2):12-14. |
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| Authors: | ZHONG Guang-xiang LIU Fu-jin CHEN Lu-lu HU Jin-qing |
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| Affiliation: | (College of pharmaceutical science, Zhejiang University of Technology, Hangzhou 310032,China) |
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| Abstract: | 1-（4-Fluorobenzyl）-2-chloro-1H-benzo d]imidazole was synthesized from o-phenylenediamine and ethyl acetoacetate by cyclization, N-alkylation, hydrolyzation and chlorination .The effects of the reaction formula on the yield of the product were studied. The optimized conditions was confirmed. The overall of the product was 56.4%. The structure of the product was confirmed by 1^H NMR. |
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| Keywords: | 1-（4-fluorobenzyl）-2-chloro-1H-benzo imidazole mizolastine intermediate synthesis |
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