| 3-甲基-2-(4-甲氧基苯基)吗啉盐酸盐的合成 |
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| 引用本文： | 贾小鹏,肖新荣,梁俊,夏岳韬,陈川,谭彬.3-甲基-2-(4-甲氧基苯基)吗啉盐酸盐的合成[J].应用化工,2011,40(1):62-63. |
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| 作者姓名： | 贾小鹏 肖新荣 梁俊 夏岳韬 陈川 谭彬 |
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| 作者单位： | 南华大学化学化工学院,湖南,衡阳,421001 |
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| 摘 要： | 以1-(4-甲氧基苯基)-2-溴-1-丙酮和乙醇胺为原料,在NMP溶剂中反应,经胺化、环合、还原、酸化得新型吗啉化合物3-甲基-2-(4-甲氧基苯基)吗啉盐酸盐,产率62.3%,新化合物结构经IR,1H NMR,MS测试技术确证。整个合成路线具有反应时间短、条件温和、收率高等优点。
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| 关 键 词： | 乙醇胺 NMP 吗啉盐酸盐 合成 |
Synthesis of 3-methyl-2-(4-methoxyphenyl) morpholine hydrochloride |
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| JIA Xiao-peng,XIAO Xin-rong,LIANG Jun,XIA Yue-tao,CHEN Chuan,TAN Bin.Synthesis of 3-methyl-2-(4-methoxyphenyl) morpholine hydrochloride[J].Applied chemical industry,2011,40(1):62-63. |
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| Authors: | JIA Xiao-peng XIAO Xin-rong LIANG Jun XIA Yue-tao CHEN Chuan TAN Bin |
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| Affiliation: | (College of Chemistry and Chemical Engineering,University of South China,Hengyang 421001,China) |
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| Abstract: | 2-(4-Methoxyphenyl)-3-methyl morpholine hydrochloride was synthesized from 2-bromo-1-(4-methoxyphenyl)-1-propanone and ethanolamine in nonproton polar solvent by cyclization reaction,reduction,acidification by divergent synthetic method,and the yield was 62.3%.The target compound structure was confirmed by IR,1H NMR,MS technology.The synthetic route has the advantages of easy operation,short reaction time,and high yield. |
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| Keywords: | NMP |
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