Potent inhibitors of the MAP kinase p38 |
| |
| Authors: | JR Henry KC Rupert JH Dodd IJ Turchi SA Wadsworth DE Cavender PH Schafer JJ Siekierka |
| |
| Affiliation: | R. W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA. |
| |
| Abstract: | The MAP kinase p38 plays a key role in the biosynthesis of the inflammatory cytokines TNF-alpha and IL-1. We have developed a novel series of potent p38 inhibitors that could lead to new methods of treatment for inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
