Mechanical properties and in vivo performance of a novel sliding-lock bioabsorbable poly-p-dioxanone stent |
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Authors: | Qimao Feng Wenbo Jiang Kun Sun Kang Sun Sun Chen Lijiao Zhao Ke Dai Ning Ma |
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Affiliation: | (1) Children’s Heart Center, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200092, China;(2) The State Key Laboratory of Metal Matrix Composites, Shanghai Jiaotong University, Shanghai, 200240, China;(3) Heart Center, Shanghai Children’s Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai, 200127, China; |
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Abstract: | A bioabsorbable poly-p-dioxanone (PPDO) stent with a novel sliding-lock structure was fabricated to treat stenotic peripheral vessels. The sliding-lock PPDO stents have greater radial strength (107 kPa) than PPDO stents with conventional net-tube structure (32 kPa). The sliding-lock PPDO stents were implanted into the iliac arteries of pigs, and implantation success rate was 90% indicating the feasibility of this design. Additionally, we found that sliding-lock PPDO stents kept vessels patent, although by 3 and 6 months post implantation, luminal diameter decreased slightly due to intimal hyperplasia. At 1 month post implantation, the stents were sparsely covered with endothelial cells, and by 6 months, the stents were mostly absorbed and inflammatory reaction gradually decreased as the stents were absorbed. This study shows favorable mechanical strength, degradability and efficacy for the sliding-lock PPDO stents, and supports further research and development of this unique design of polymer stents for applications in vascular devices. |
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