| Preparation and Degradation Characteristics of Poly （d,l-lactide） Composite Films |
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| 引用本文： | CHEN Lei YAN Yuhua LI Jianhua LI Shipu. Preparation and Degradation Characteristics of Poly （d,l-lactide） Composite Films[J]. 武汉理工大学学报(材料科学英文版), 2007, 22(4): 691-694. DOI: 10.1007/s11595-006-4691-9 |
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| 作者姓名： | CHEN Lei YAN Yuhua LI Jianhua LI Shipu |
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| 作者单位： | Biomedical Materials and Engineering Research Center, Wuhan University of Technology, Wuhan 430070, China |
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| 基金项目： | 国家重点基础研究发展计划(973计划) |
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| 摘 要： | PDLLA/CHI/β-TCP/NGF composite films were prepared by a solvent evaporation method. The degradation characteristics of the poly （d, l-lactide） composite films were studied in vitro and in vivo. The acidity produced by poly （d, l-lactide） materials was not obvious. Adding chitosan and β-TCP can relieve the acidity problem and improve strength performance of films. The NGF has influences on the degradation characteristics of films. It is verified that PDLLA/CHI/β-TCP/NGF composite films prepared by solvent evaporation method have excellent degradation characteristics. It can be used as a perfect biomaterial for repairing nerve injuries.
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| 关 键 词： | 聚乙烯 壳聚糖 β-TCP 神经生长因素 降解作用 |
| 收稿时间： | 2006-04-16 |
| 修稿时间： | 2007-03-09 |
Preparation and degradation characteristics of poly (d,l-lactide) composite films |
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| Chen Lei,Yan Yuhua,Li Jianhua,Li Shipu. Preparation and degradation characteristics of poly (d,l-lactide) composite films[J]. Journal of Wuhan University of Technology. Materials Science Edition, 2007, 22(4): 691-694. DOI: 10.1007/s11595-006-4691-9 |
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| Authors: | Chen Lei Yan Yuhua Li Jianhua Li Shipu |
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| Affiliation: | (1) Biomedical Materials and Engineering Research Center, Wuhan University of Technology, Wuhan, 430070, China |
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| Abstract: | PDLLA/CHI/β-TCP/NGF composite films were prepared by a solvent evaporation method. The degradation characteristics of the poly (d, l-lactide) composite films were studied in vitro and in vivo. The acidity produced by poly (d, l-lactide) materials was not obvious. Adding chitosan and β-TCP can relieve the acidity problem and improve strength performance of films. The NGF has influences on the degradation characteristics of films. It is verified that PDLLA/CHI/β-TCP/NGF composite films prepared by solvent evaporation method have excellent degradation characteristics. It can be used as a perfect biomaterial for repairing nerve injuries. Funded by “973” Project (No. 2005CB623905) |
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| Keywords: | poly (d,l-lactic acid) (PDLLA) chitosan (CHI) nerve growth factor (NGF) degradation characteristics |
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