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Dual stimuli-responsive polymeric hollow nanocapsules as “smart” drug delivery system against cancer |
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| Authors: | Rana Jahanban-Esfahlan Bakhshali Massoumi Mojtaba Abbasian Amir Farnudiyan‐Habibi Hadi Samadian Aram Rezaei |
| Affiliation: | 1. Department of Medical Biotechnology, School of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz, Iran;2. Department of Chemistry, Payame Noor University , Tehran, Iran;3. Department of Pharmaceutical Biomaterials, Faculty of Pharmacy, Tehran University of Medical Sciences , Tehran, Iran;4. Medical Biomaterials Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences , Tehran, Iran;5. Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences , Kermanshah, Iran |
| Abstract: | ABSTRACT Novel thermal- and pH-responsive hollow nanocapsules (HNCaps) were fabricated through the grafting of a thiol-end capped PNIPAAm-b-PAA by thiol-ene “click” reaction onto PMMA HNCaps. The lowest critical solution temperature (LCST) of the fabricated HNCaps was obtained as 38–40°C. The fabricated nanosystem was loaded with doxorubicin hydrochloride (Dox), and its drug loading and encapsulation efficiencies were obtained as 62 and 53%, respectively. The in vitro stimuli-responsive drug release behavior of the fabricated nanomedicine was investigated extensively. The anticancer activity of the drug-loaded HNCaps was evaluated using MTT assay against MCF7 cells. The results exhibited excellent potential of nanosystem as a drug delivery system (DDS) for cancer chemotherapy. |
| Keywords: | Nanomedicine cancer chemotherapy hollow nanocapsules stimuli responsive |