Novel antibacterial modalities against methicillin resistant Staphylococcus aureus derived from plants |
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| Authors: | Jiao Li Donghong Liu Xiaojun Tian Shigenobu Koseki Shiguo Chen Xingqian Ye |
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| Affiliation: | 1. Department of Food Science and Nutrition, National Engineering Laboratory of Intelligent Food Technology and Equipment, Zhejiang University, Hangzhou, Zhejiang, China;2. Key Laboratory for Agro-Products Postharvest Handling of Ministry of Agriculture, Zhejiang Key Laboratory for Agro-Food Processing, Hangzhou, Zhejiang, China;3. School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, USA;4. Graduate School of Agricultural Science, Hokkaido University, Sapporo, Japan |
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| Abstract: | AbstractMethicillin-resistant Staphylococcus aureus (MRSA) is a notorious bacterial pathogen that induces high mortality and morbidity. Due to the emergence of multiple resistance, antibiotic treatments are rapidly becoming ineffective for the related infections. Natural products, especially those derived from plants, have been proven to be effective agents with unique antibacterial properties through different mechanisms. This review interprets the resistance mechanisms of MRSA with the aim to conquer public health threat. Further, recent researches about plant antimicrobials that showed remarkable antibacterial activity against MRSA are recorded, including the crude plant extracts and purified plant-derived bioactive compounds. Novel anti-MRSA modalities of plant antimicrobials such as alteration in efflux pump, inhibition of pyruvate kinase, and disturbance of quorum sensing in MRSA are also summarized which may be promising alternatives to antibacterial drug development in future. |
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| Keywords: | MRSA plant antimicrobials efflux pump pyruvate kinase quorum sensing |
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