Study of hemocompatibility and endothelial cell interaction of tecoflex-based electrospun vascular grafts |
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| Authors: | Vera S. Chernonosova Alexander A. Gostev Yuriy A. Chesalov Andrey A. Karpenko Alexander M. Karaskov Pavel P. Laktionov |
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| Affiliation: | 1. Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation, Novosibirsk, Russia;2. Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia;3. vera_mal@niboch.nsc.ru;5. Boreskov Institute of Catalysis, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia |
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| Abstract: | AbstractEnsuring long-term functioning and efficient endothelialization of small diameter vascular grafts (VG) is an urgent task of tissue engineering. A solution may be to use electrospun VGs prepared from blends polyurethane with gelatin and/or bivalirudin. Here, properties of 3D matrices were explored by SEM, contact angle measurements and IR spectroscopy, and their interaction with blood and endothelial cells was studied. Introduction of gelatin into matrices enhanced adhesion and proliferation of endotheliocytes and enabled adhesion of platelets, whereas bivalirudin inhibited platelet adhesion while having no negative effect on the adhesion and proliferation of endothelial cells. |
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| Keywords: | Electrospinning vascular graft polyurethane gelatin bivalirudin HUVEC hemocompatibility |
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