Fabrication and characterization of colon specific eudragit coated graphene oxide microsphere for sustained delivery of tramadol hydrochloride |
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| Authors: | Mahesh P More Ganesh B Patil Sanjay D Thakare Pravin O Patil Ashwini G Patil |
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| Affiliation: | 1. Post Graduate Department of Pharmaceutics, H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur, India;2. Department of Pharmaceutics, Shri Vile Parle Kelwani Mandals, Institute of Pharmacy, Dhule, India;3. Department of Microbiology and Biotechnology, R. C. Patel Arts, Commerce and Science College, Shirpur, India |
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| Abstract: | ABSTRACTPresent investigation reports a straight forward method for synthesis of graphene oxide (GO) followed by fabrication of graphene oxide microsphere (GMS) using water in oil (w/o) emulsification technique. For colon specific drug delivery, enteric coating is desirable, which was done using Eudragit S100 and characterized by Fourier transform Infrared Spectroscopy (FTIR). The surface morphology of fabricated microsphere was confirmed using scanning electron microscopy (SEM). Drug loaded microspheres demonstrated a high payload capacity for model drug tramadol hydrochloride (TmH). The comparative In-vitro drug release showed around 72.37% release from uncoated microspheres, whereas eudragit coated microspheres retarded the drug release upto 10 h. |
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| Keywords: | Graphene oxide microsphere fabrication colon targeted drug delivery system irritable bowel disease |
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