| 季铵化两亲性壳聚糖衍生物载药性质研究 |
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| 引用本文： | 丁德润.季铵化两亲性壳聚糖衍生物载药性质研究[J].精细化工,2012,29(6):549-553. |
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| 作者姓名： | 丁德润 |
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| 作者单位： | 上海工程技术大学化学化工学院,上海,201620 |
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| 基金项目： | 上海工程技术大学基金项目（2011XY22） |
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| 摘 要： | 合成新型季铵化两亲性壳聚糖衍生物(DEAE-CMC)。用乳化交联固化法制备DEAE-CMC/VB12载药微球。用激光粒径仪、扫描电镜对微球的大小和形态进行表征。载药微球的平均粒径为4.53μm。在pH=7.4磷酸盐缓冲溶液中,DEAE-CMC/VB12载药微球体外药物释放达到平衡时间为60 h,药物包封率为33.70%,载药量为12.47%,平衡时药物累积释放率为56.30%。
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| 关 键 词： | 壳聚糖 两亲性 维生素B12 微球 功能材料 |
| 收稿时间： | 2012/1/17 0:00:00 |
| 修稿时间： | 2012/3/21 0:00:00 |
Characterization and Drugdelivery Behavior of Quaternary Amphiphilic Chitosan Derivatives |
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| DING De-run.Characterization and Drugdelivery Behavior of Quaternary Amphiphilic Chitosan Derivatives[J].Fine Chemicals,2012,29(6):549-553. |
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| Authors: | DING De-run |
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| Affiliation: | College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science |
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| Abstract: | A series of novel quaternary amphiphilic chitosan derivatives(DEAE-CMC) were prepared.The DEAE-CMC/VB12 microspheres were prepared by "emulsion—crosslinking—solidification" method.The particle size,morphology and microstructure of the microspheres were analyzed by laser particle size analyzer and scanning electron microscopy(SEM).The results show that the average particle size of the DEAE-CMC/VB12 microspheres was 4.53 μm.The drug release behavior of the DEAE-CMC/VB12 microspheres in pH=7.4 phosphate buffer solutions showed that: the release equilibrium time was 60 h,the entrapment efficiency was 33.70%,and the loading content was 12.47%.The accumulated release ratio of the drug was 56.30% at equilibrium. |
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| Keywords: | Chitosan amphiphilic VB12 microsphere |
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