载药纳米颗粒与血管支架自装配机理和方法

在综合分析微器件三维自装配研究成果的基础上，指出目前研究方法在纳米级微器件三维功能结构自装配中存在的问题，提出综合应用介电泳动、毛细作用和疏水性等微观作用力，实现载药纳米颗粒与血管支架的自装配，并对实现自装配所涉及的介电泳力和毛细力的控制机理和方法、载药纳米颗粒药物的选择和制作、裸支架本体结构的优化设计以及自装配实现工艺流程等关键技术进行了研究，给出了自装配的实现工艺平台以及相应的电场空间分布仿真结果。上述研究成果为最终研制纳米颗粒载药涂层支架提供了可行的方案。

MECHANISM AND METHOD OF DRUG-LOADING NANO-PARTICLES AND STENT SELF-ASSEMBLY

On the basis of comprehensively analyzing the fruits of self-assembly fields, some problems of the self-assembly method for application of the nano-particle 3D self-assembly are pointed out, and a new method which realizes the self-assembly of drug-loading nano-particles and stent by comprehensively applying the micro-forces such as dielectrophore-tic force, capillary force, and hydrophobic force etc. is put forward. And many key technologies for implement of nano-particle and stent self-assembly are studied, including the self-assembly mechanism and method of using dielectrophore sis force and capillary force, the optimal design method of the stent, and the choice and making for nano-particles drug etc. In the end, the implement process workbench of self-assembly and the simulation results of electric field spatial layout are presented. The aforementioned research results provide the feasible scenario for the development of drug-loading nanoparticle coating stent ultimately.