Antifungal Abietane-Type Diterpenes from the Cones of Taxodium distichum Rich |
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Authors: | Norihisa Kusumoto Tatsuya Ashitani Tetsuya Murayama Koichi Ogiyama Koetsu Takahashi |
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Affiliation: | (1) The United Graduate School of Agricultural Science, Iwate University, 18-8, Ueda 3-chome, Morioka Iwate, 020-8550, Japan;(2) Faculty of Agriculture, Yamagata University, 1-23, Wakaba-machi, Tsuruoka Yamagata, 997-8555, Japan |
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Abstract: | The chemical composition of Taxodium distichum cones and the antifungal activities of twelve diterpenoids against two wood decay fungi, Trametes versicolor (white-rot) and Fomitopsis palustris (brown-rot) were examined. The chemical composition of the major extractive fraction, the n-C6H14 extract, was evaluated and its antifungal properties were identified. Twelve diterpenoids including ten abietane-type components were isolated from the n-C6H14 extract: 6,7-dehydroferruginol (1), ferruginol (2), 6,7-dehydroroyleanone (3), sandaracopimaric acid (4), taxodione (5), taxodal (6), taxodone (7), sugiol (8), xanthoperol (9), salvinolone (10), 5,6-dehydrosugiol (11), and 14-deoxycoleon U (12). Compounds 5 and 12 were highly active against both wood-decay fungi. In particular, the activities of these compounds against F. palustris were potent. The results suggest that the position and the number of hydroxyl groups on abietane-type structures may be related to antifungal activities against T. versicolor and F. palustris. |
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