| 芯片上单链DNA生物膜的弯电性能分析 |
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| 引用本文： | 李晶晶,徐凌伟,陈建中,张能辉.芯片上单链DNA生物膜的弯电性能分析[J].材料工程,2011(10):11-14. |
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| 作者姓名： | 李晶晶 徐凌伟 陈建中 张能辉 |
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| 作者单位： | 1. 上海市应用数学和力学研究所上海市力学在能源工程中的应用重点实验室,上海200072;上海大学理学院力学系,上海200444
2. 上海市应用数学和力学研究所上海市力学在能源工程中的应用重点实验室,上海,200072 |
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| 基金项目： | 国家自然科学基金(10872121);上海市教育委员会科研创新项目(09YZ07);国家杰出青年基金(10725209);上海市重点学科建设(S30106) |
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| 摘 要： | 基于非线性Poisson-Boltzmann (NLPB)方程和液晶薄膜弯电理论,利用Fogolari修正公式,建立了单链DNA (ssDNA)分子结构特征、溶液离子浓度等因素与生物膜电势、芯片宏观变形之间的非线性多尺度关系.结合现有的实验数据,拟合了单链DNA生物薄膜的弯电系数,并将生物膜电势分布及芯片变形的线性预测...
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| 关 键 词： | DNA生物膜 电势 变形 弯电效应 非线性Poisson-Boltzmann方程 |
Flexoelectric Analysis of Single-stranded DNA Biofilm on Chip |
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| LI Jing-jing,XU Ling-we,CHEN Jian-zhong,ZHANG Neng-hui.Flexoelectric Analysis of Single-stranded DNA Biofilm on Chip[J].Journal of Materials Engineering,2011(10):11-14. |
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| Authors: | LI Jing-jing XU Ling-we CHEN Jian-zhong ZHANG Neng-hui |
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| Affiliation: | 1,2(1 Shanghai Key Laboratory of Mechanics in Energy Engineering, Shanghai Institute of Applied Mathematics and Mechanics, Shanghai 200072,China;2 Department of Mechanics,College of Sciences,Shanghai University,Shanghai 200444,China) |
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| Abstract: | Based on nonlinear Poisson-Boltzmann equation(NLPB) and flexoelectric theory of liquid crystal thin films,with the help of Fogolari’s correct formula,a nonlinear multiscale relation among single-stranded DNA(ssDNA) molecule structure feature,salt solution concentration and biofilm electrostatic potential,chip macroscopic deformation is formulated.The flexoelectric coefficient is obtained by curve fitting based on existing experimental data.The linear and nonlinear predictions for biofilm electrostatic potential and chip deformation are compared to validate the present nonlinear multiscale relation.The influences of DNA fragment length,packing density on chip deformation are also investigated.The results show that chip deformation increase with the enhancement of DNA fragment length and packing density. |
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| Keywords: | DNA biofilm electrostatic potential deformation flexoelectric effect nonlinear Poisson-Boltzmann equation |
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