| 手性BINOL磷酸催化剂在不对称转化中的应用 |
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| 引用本文： | 姚元勇,肖春霞,唐帮成,付蓉,张晶.手性BINOL磷酸催化剂在不对称转化中的应用[J].广州化工,2014(19):8-10. |
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| 作者姓名： | 姚元勇 肖春霞 唐帮成 付蓉 张晶 |
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| 作者单位： | 铜仁学院材料与化学工程学院，梵净山特色动植物资源重点实验室，贵州 铜仁 554300 |
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| 基金项目： | 贵州省教育厅“125”重大科技专项[2012]018资助；铜市科研[2014]40-3； trxyS1343。 |
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| 摘 要： | 3,3＇-位基团取代手性BINOL磷酸在不对称催化反应中具有较强的催化活性。其原因在于：（1）手性BINOL磷酸具有较强的（P=O）Lewis碱和较强的（P-OH）Lewis酸,可以有效通过与催化底物之间形成氢键,激活反应体系;（2）在手性BINOL磷酸的3,3＇-位上引入阻位基团,建立有效的手性环境,可以成功地诱导不对称转化。本文例举了通过氢键相互作用,手性BINOL磷酸催化剂成功地诱导不对称催化反应。
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| 关 键 词： | 手性BINOL磷酸 不对称催化 催化剂 |
Application of Chiral BINOL Phosphoric Acid Catalyst to Asymmetric Transformations |
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| YAO Yuan-yong,XIAO Chun-xia,TANG Bang-cheng,FU Rong,ZHANG Jing.Application of Chiral BINOL Phosphoric Acid Catalyst to Asymmetric Transformations[J].GuangZhou Chemical Industry and Technology,2014(19):8-10. |
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| Authors: | YAO Yuan-yong XIAO Chun-xia TANG Bang-cheng FU Rong ZHANG Jing |
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| Affiliation: | YAO Yuan-yong;XIAO Chun-xia;TANG Bang-cheng;FU Rong;ZHANG Jing;Collage of Material and Chemical Engineering,Fanjing Mountain Key Laboratory of Special Animal and Plant Resource,Tongren University; |
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| Abstract: | Chiral BINOL phosphoric acid bearing suitable substituted groups at 3,3＇ positions performs potent catalytic activity in the asymmetric transformations. The cause of catalytic activity of catalyst were depicted by incorporated stronger Lewis base （ P = 0） and Lewis acid （ P - OH）, by which reaction system was allowed to be activated through potent hydrogen bonding interactions of catalyst with substrates. In addition, introducing bulky substituted groups to 3, 3＇positions of BINOL phosphoric acid catalyst can potently build chiral environment to induce successfully asymmetric transformations. Some classic examples of asymmetric transformations in the presence of chiral BINOL phosphoric acid catalyst with hydrogen bonding interactions were listed. |
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| Keywords: | chiral BINOL phosphoric acid asymmetric catalysis catalyst |
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