Pneumococcal polysaccharide vaccine in children with chronic renal disease: a prospective study of antibody response and duration |
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| Authors: | SL Furth AM Neu B Case HM Lederman M Steinhoff B Fivush |
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| Affiliation: | Division of Pediatric Nephrology, Immunology, and Infectious Disease, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21287-2467, USA. |
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| Abstract: | We studied the antibody response to pneumococcal serotypes 3 and 14 after pneumococcal polysaccharide vaccine was administered to 41 children with renal disease. One month after vaccination, 76% and 61% of patients achieved at least a twofold titer rise to serotypes 3 and 14, respectively; this finding was comparable to historic control values. One year after vaccination, the majority of patients retained protective antibody levels. Achieving a titer > or = 1.0 microgram/ml IgG at 1 month was highly predictive of retaining a protective antibody level > or = 0.15 microgram/ml at 1 year. |
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