HIV type 1 subtypes in Malaysia include B, C, and E |
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Authors: | TM Brown KE Robbins M Sinniah TS Saraswathy V Lee LS Hooi B Vijayamalar CC Luo CY Ou J Rapier G Schochetman ML Kalish |
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Affiliation: | Division of AIDS/STD/TB/Laboratory Research, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. |
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Abstract: | Peripheral blood mononuclear cell specimens were collected from 13 HIV-1-infected IV drug users in Kuala Lumpur, Malaysia, as well as one HIV-infected baby, between 1992 and 1993. DNA was then amplified by nested polymerase chain reaction and a 345-bp fragment of the C2V3 region of the env gene was sequenced. 11 of the 14 Malaysian sequences clustered with the B' subtype, one different from the typical subtype B US strains HIVMN and HIVSF2. Two sequences grouped in the C subtype and had sister taxa closer to the Indian C subtype sequences than those from Zambia. The sequence from the infant was identified as a subtype E virus, grouped more closely with subtype E strains from Thailand than subtype E viruses from the Central African Republic. |
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