| 法莫替丁合成工艺的改进 |
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| 引用本文： | 周媛,杜芳艳. 法莫替丁合成工艺的改进[J]. 化学与生物工程, 2000, 17(5): 19-20 |
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| 作者姓名： | 周媛 杜芳艳 |
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| 作者单位： | 1. 三峡大学化学化工系,湖北,宜昌,443003
2. 榆林师范专科学校,陕西,榆林,719000 |
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| 摘 要： | 采用 2 二氨基亚甲氨基 4 脒基硫代甲基噻唑二盐酸盐直接与N 氨磺酰基 β 氯丙脒缩合得法莫替丁 ,减少了合成步骤 ,总收率提高到 4 0 %。
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| 关 键 词： | 2-二氨基亚甲氨基-4-脒基硫代甲基噻唑二盐酸盐 N-氨磺酰基-β-氯丙脒 法莫替丁 合成 |
| 修稿时间： | 2000－02－14 |
Improved Synthesis of Famotidine |
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| ZHOU Yuan,DU Fang-yan. Improved Synthesis of Famotidine[J]. Chemistry & Bioengineering, 2000, 17(5): 19-20 |
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| Authors: | ZHOU Yuan DU Fang-yan |
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| Affiliation: | ZHOU Yuan 1,DU Fang yan 2 |
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| Abstract: | Famotidine is formed with condensing between 2 diaminomethylene amino 4 chlor methylthiazole hydrochloride and 2 diaminomethylene amino 4 amidino thiomethylthiazole dihydrochlride.The step is reduced but the total receipt rate is raised to 40%. |
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| Keywords: | diaminomethylene amino 4 chlor methylthiazole hydrochloride 2 diaminomethylene amino 4 amidino thiomethylthiazole dihydrochlride famotidine synthesis |
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