| 肝素/壳聚糖微胶囊的制备及其抗凝血性能 |
| |
| 引用本文： | 梁艳,宋家鸿,陈荆晓,陈敬华. 肝素/壳聚糖微胶囊的制备及其抗凝血性能[J]. 食品与生物技术学报, 2015, 34(3): 295-301 |
| |
| 作者姓名： | 梁艳 宋家鸿 陈荆晓 陈敬华 |
| |
| 作者单位： | 江南大学 药学院,江苏 无锡 214122;江南大学 药学院,江苏 无锡 214122;江南大学 药学院,江苏 无锡 214122;江南大学 药学院,江苏 无锡 214122 |
| |
| 摘 要： | 采用层层自组装(LbL)技术制备了肝素/壳聚糖(HEP/CHI)5微胶囊,并研究了其抗凝血性能、胃肠道稳定性和毒副作用等。结果表明:该微胶囊具有球形结构;在p H 5.0、7.4中肝素能够缓慢可控地释放;在p H 5.0、7.4以及模拟胃液、肠液条件下具有稳定性;APTT法和全凝固实验验证了它在体外具有良好的抗凝血效果;并且对内皮细胞无细胞毒性。因此,该微胶囊有望作为口服剂型,用于临床肝素给药。
|
| 关 键 词： | 微胶囊 肝素 抗凝血 层层自组装 口服剂型 |
Preparation of Heparin/Chitosan Microcapsule for Anticoagulation Study |
| |
| LIANG Yan,SONG Jiahong,CHEN Jingxiao and CHEN Jinghua. Preparation of Heparin/Chitosan Microcapsule for Anticoagulation Study[J]. Journal of Food Science and Biotechnology, 2015, 34(3): 295-301 |
| |
| Authors: | LIANG Yan SONG Jiahong CHEN Jingxiao CHEN Jinghua |
| |
| Affiliation: | School of Pharmaceutical Science,Jiangnan University,Wuxi 214122,China;School of Pharmaceutical Science,Jiangnan University,Wuxi 214122,China;School of Pharmaceutical Science,Jiangnan University,Wuxi 214122,China;School of Pharmaceutical Science,Jiangnan University,Wuxi 214122,China |
| |
| Abstract: | Heparin/chitosan(HEP/CHI)5 microcapsules for anticoagulation were prepared by Layer-by-layer(LbL) technique. The stability of(HEP/CHI)5 microcapsules under pH 5.0 and 7.4,simulated gastric and intestinal juices conditions was studied respectively,APTT anticoagulant time and cytotoxicity of microcapsules against endothelial cells were estimated. Results indicated that(HEP/CHI)5 microcapsules were of spherical structure and stable in different simulated physiological milieus;they could behave favorable anticoagulant efficacy with no significant cytotoxicity. Thus,(HEP/CHI)5 microcapsules were promising for clinical heparin administration as a novel oral dosage form. |
| |
| Keywords: | microcapsule heparin anticoagulation LBL oral dosage form |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《食品与生物技术学报》浏览原始摘要信息 |
|
点击此处可从《食品与生物技术学报》下载免费的PDF全文 |
|
