Synthesis, characterization polymerization and antibacterial properties of novel thiophene substituted acrylamide |
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| Authors: | Maher Z. Elsabee Eman A. Ali Samia M. Mokhtar Mohamed Eweis |
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| Affiliation: | aDepartment of Chemistry, Faculty of Science, Cairo University, Cairo 12613, Egypt;bDepartment of Chemistry, Faculty of Science, College of Women, Ein Shams University, Cairo, Egypt;cDepartment of Botany, Faculty of Science, Cairo University, Cairo 12613, Egypt |
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| Abstract: | Ethyl 2-acrylamido-4,5,6,7-tetrahydrobenzo [b] thiophene-3-carboxylate (ETTCA) has been synthesized and its structure has been elucidated by elemental analysis and spectral tools. Free radical polymerization of (ETTCA) has been conducted in several solvents using azobisisobutyronitrile (AIBN) as an initiator. The kinetic parameters of polymerization of the ETTCA were investigated, and it was found that the polymerization reaction follows the conventional free radical scheme. The overall activation energy of polymerization ΔE was determined (ΔE = 45.11 kJ mol−1). The copolymerization of ETTCA with three conventional monomers was carried out in dioxane at 65 °C. The monomer reactivity ratios for the copolymerization of ETTCA with methyl methacrylate (MMA), vinyl acetate (VA) and vinyl ether (VE) were calculated. Thermal stability of the ETTCA polymer and its copolymers were investigated by thermogravimetric analysis. It has been found that the prepared polymer (PETTCA) and its copolymers with VA have moderate biological activity and highly dependent on the copolymer composition. |
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| Keywords: | Thiophene Acrylamide derivative Methyl methacrylate Vinyl acetate Vinyl ether Monomer reactivity ratios Thermogravimetric analysis Biological activity |
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