A study of low-energy ion induced radiolysis of thiol-containing amino acid cysteine in the solid and aqueous solution states |
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Authors: | Zhigang Ke Qing Huang Bingrong Dang Yilin Lu Hang Yuan Shuqing Zhang Zengliang Yu |
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Affiliation: | 1. Key Laboratory of Ion Beam Bio-engineering, Institute of Plasma Physics of Chinese Academy of Sciences, 350 Shushanhu Road, P.O. Box 1126, Hefei 230031, People’s Republic of China;2. Institute of Modern Physics, Chinese Academy of Sciences, 509 Nanchang Road, Lanzhou 730000, People’s Republic of China;3. Department of Physics, Anhui University, Hefei 230031, People’s Republic of China |
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Abstract: | The radiolysis of cysteine under plasma discharge and irradiation of low-energy ion beam was investigated. The damage of cysteine in aqueous solution under discharge was assessed via the acid ninhydrin reagent and the yield of cystine produced from the reaction was analyzed by FTIR. In addition, the generation of hydrogen sulfide was also identified. The destruction of solid cysteine under low-energy ion beam irradiation was estimated via monitoring IR bands of different functional groups (–SH, –NH3, –COO?) of cysteine, and the production of cystine from ion-irradiated solid cysteine after dissolution in water was also verified. These results may help us to understand the inactivation of sulphydryl enzymes under direct and indirect interaction with the low-energy ion irradiation. |
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