Sesame oil in injectable gold: two drugs in one? |
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Authors: | S ten Wolde F Engels AM Miltenburg EA Kuijpers GI Struijk-Wielinga BA Dijkmans |
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Affiliation: | Department of Rheumatology, University Hospital Leiden, The Netherlands. |
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Abstract: | To investigate the potential anti-inflammatory effects of sesame oil, which is present in the injectable gold preparation Auromyose, the synthesis of tumour necrosis factor alpha (TNF-alpha), prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) by in vitro stimulated blood cells was measured before, during and after 12 weeks of dietary supplementation with 18 g of sesame oil daily in 11 healthy male volunteers. Neither TNF-alpha, PGE2 nor LTB4 production levels showed statistically significant changes during the 12 weeks of dietary supplementation with sesame oil. These results do not suggest an anti-inflammatory effect of sesame oil as present in injectable gold preparations which are used in the treatment of rheumatoid arthritis. |
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