Muscarinic-receptor antagonist scopolamine rescues hippocampal neurons from death induced by glutamate |
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| Authors: | A Rami J Krieglstein |
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| Affiliation: | Department of Pharmacology, Monash University, Clayton, Vic., Australia. cowenm@its-med.cc.monash.edu.au |
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| Abstract: | Preprodynorphin and preproenkephalin mRNA expression was examined in the CNS of two rat strains, the alcohol-preferring Fawn-Hooded (FH) and the alcohol-non-preferring Wistar-Kyoto (WKY), using in situ hybridisation histochemistry. Relative to the WKY, the FH showed significantly lower levels of preproenkephalin mRNA in the striatum and nucleus accumbens (-24% and -17% respectively), but a higher level of preprodynorphin mRNA in the hippocampus (+33%). The depressed level of preproenkephalin mRNA in the nucleus accumbens may be implicated in alcohol-seeking behaviour. |
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