Modified poly(caprolactone trifumarate) with embedded gelatin microparticles as a functional scaffold for bone tissue engineering |
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Authors: | Nisreen Mohammed Nagi Al‐Namnam Kah Hwi Kim Wen Lin Chai Kien Oon Ha Chong Huat Siar Wei Cheong Ngeow |
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Affiliation: | 1. Department of Oro‐Maxillofacial Surgical and Medical Sciences, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia;2. Department of Physiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia;3. Department of Restorative Dentistry, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia |
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Abstract: | Bone tissue engineering offers high hopes in reconstructing bone defects that result from trauma, infection, tumors, and other conditions. However, there remains a need for novel scaffold materials that can effectively stimulate ossification with appropriate functional properties. Therefore, a novel injectable, biodegradable, and biocompatible scaffold made by incorporating modified poly(caprolactone trifumarate) (PCLTF) with embedded gelatin microparticles (GMPs) as porogen is developed. Specifically, in vitro and in vivo tests were carried out. For the latter, to determine the osteogenic ability of PCLTF‐GMPs scaffolds, and to characterize bone‐formation, these scaffolds were implanted into critical‐sized defects of New Zealand white rabbit craniums. Field Emission Scanning Electron Microscope (FESEM) demonstrated cells of varying shapes attached to the scaffold surface in vitro. The PCLTF‐GMPs demonstrated improved biocompatibility in vivo. Polyfluorochrome tracers detected bone growth occurring in the PCLTF‐GMPs filled defects. By incorporating PCLTF with GMPs, we have fabricated a promising self‐crosslinkable biocompatible and osteoconducive scaffold for bone tissue engineering. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133, 43711. |
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Keywords: | applications biocompatibility biomaterials biomedical applications polyesters |
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