Modelling of the Corynebacterium glutamicum biosynthesis under aerobic fermentation conditions |
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| Authors: | Kaibiao Sun Andrzej Kasperski Yuan Tian Lansun Chen |
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| Affiliation: | aSchool of Control Science and Engineering, Dalian University of Technology, Dalian 116024, People's Republic of China;bFaculty of Mathematics, Computer Science and Econometrics, Bioinformatics Factory, University of Zielona Gora, Szafrana 4a, 65-516 Zielona Gora, Poland;cSchool of Information Engineering, Dalian University, Dalian 116622, People's Republic of China;dSchool of Mathematical Science, Dalian University of Technology, Dalian 116024, People's Republic of China |
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| Abstract: | This work concerns the modelling of the Corynebacterium glutamicum biosynthesis. At the beginning, the impulsive growth model of C. glutamicum under glutamate inhibition is established. According to this model, the analysis of the bioprocess stability is presented. Then, new objective functions are proposed and optimisation of C. glutamicum growth is presented. The results of the optimisation indicate that, although the growth of C. glutamicum is an aerobic process, the maximum of biomass productivity occurs under controlled penetration into the area of aerobic fermentation. Analytical results presented in this work are validated by numerical simulations. |
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| Keywords: | Aerobic fermentation Biomass biosynthesis Bioprocess stability Corynebacterium glutamicum Optimisation Periodic solutions |
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