Dietary grape seed extract ameliorates symptoms of inflammatory bowel disease in IL10‐deficient mice |
| |
| Authors: | Hui Wang Yansong Xue Hanying Zhang Yan Huang Guan Yang Min Du Mei‐Jun Zhu |
| |
| Affiliation: | 1. Department of Animal Science, University of Wyoming, , Laramie, WY, USA;2. School of Food Science, Washington State University/University of Idaho, , Pullman, WA, USA;3. Department of Animal Science, Washington State University, , Pullman, WA, USA |
| |
| Abstract: | Grape seed extract (GSE) is a by‐product of the wine industry, with abundant polyphenolic compounds known for their anti‐inflammatory and anti‐oxidative effects. Using IL10‐deficient mice (IL10KO), here we showed that GSE (1% of dry feed weight) ameliorated inflammatory bowel disease indices, increased colonic goblet cell numbers and decreased myeloperoxidase levels in the large intestine. Concomitantly, GSE supplementation attenuated inflammation, decreased the expression of pore forming tight junction protein claudin2, and increased levels of Lactobacilli and Bacteroides in the gut microbiota of IL10KO mice. In summary, our study shows that GSE has protective roles on inflammatory bowel disease through altering gut inflammation, tight junction protein expression, and gut microbiota composition. |
| |
| Keywords: | Epithelium Grape seed extract Inflammatory bowel disease Intestine IL‐10 Microbiota |
|
|
