SEBS elastomers for fabrication of microfluidic devices with reduced drug absorption by injection molding and extrusion |
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| Authors: | Karel Domansky Josiah D Sliz Norman Wen Christopher Hinojosa II" target="_blank">Guy ThompsonII Jacob P Fraser Tiama Hamkins-Indik Geraldine A Hamilton Daniel Levner Donald E Ingber |
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| Affiliation: | 1.Wyss Institute for Biologically Inspired Engineering at Harvard University,Boston,USA;2.Vascular Biology Program and Departments of Surgery,Boston Children’s Hospital and Harvard Medical School,Boston,USA;3.Harvard John A. Paulson School of Engineering and Applied Sciences,Harvard University,Cambridge,USA;4.Seattle,USA;5.Emulate, Inc.,Boston,USA |
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| Abstract: | The majority of microfluidic devices used for cell culture, including Organ-on-a-Chips (Organ Chips), are fabricated using polydimethylsiloxane (PDMS) polymer because it is flexible, optically clear, and easy to mold. However, PDMS possesses significant challenges for high volume manufacturing and its tendency to absorb small hydrophobic compounds limits its usefulness as a material in devices used for drug evaluation studies. Here, we demonstrate that a subset of optically clear, elastomeric, styrenic block copolymers based on styrene-ethylene-butylene-styrene exhibit reduced absorption of small hydrophobic molecules and drug compounds compared to PDMS and that they can be fabricated into microfluidic devices with fine features and the flexibility required for Organ Chips using mass production techniques of injection molding and extrusion. |
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