| 诺氟沙星明胶磁性微球的研制及表征 |
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| 引用本文： | 王彦卿,张朝平. 诺氟沙星明胶磁性微球的研制及表征[J]. 无机材料学报, 2005, 20(1): 77-82 |
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| 作者姓名： | 王彦卿 张朝平 |
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| 作者单位： | 贵州大学化学与生化学院化学系, 贵阳 550025 |
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| 基金项目： | 贵阳市科技开发基金[2001(01)]贵州省教育厅科技基金[2002(101)] |
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| 摘 要： | 利用明胶的生物相容性及经戊二醛处理可使其固化的特性, 以Fe3O4作为磁性内核, 以液体石蜡为有机分散介质, 通过反相悬液冷冻凝聚法制备了强磁性的诺氟沙星明胶核壳微球, 用IR、SEM、TEM、UV/Vis等技术对微球进行了性能表征, 结果表明: 微球成球性好, 无粘连, 平均直径为5～10μm, Fe3O4的含量为19%, 明胶的含量为74.8%, 微球载药率(w/w)为6.2%, 药物包裹率为61.4%, 5h释放药物为74.4%, 微球具有较好的缓释性.
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| 关 键 词： | 明胶 诺氟沙星 磁性微球 控制释放 |
| 文章编号： | 1000-324X(2005)01-0077-06 |
| 收稿时间： | 2003-12-01 |
| 修稿时间： | 2004-03-22 |
Preparation and Characterization of Magnetic Norfloxacin Gelatin Microspheres |
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| WANG Yan-Qing,ZHANG Chao-Ping. Preparation and Characterization of Magnetic Norfloxacin Gelatin Microspheres[J]. Journal of Inorganic Materials, 2005, 20(1): 77-82 |
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| Authors: | WANG Yan-Qing ZHANG Chao-Ping |
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| Affiliation: | Department of Chemsitry, College of Chemistry and biochemistry, Guizhou University, Guiyang 550025, China |
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| Abstract: | Based on the biological compatibility of gelatin in water and its solidification by glutaradehyde, the magnetic norfloxacin gelatin core-shell microspheres were prepared by means of the reverse phase suspension cold-condensation method using Fe3O4 as core and glutaric dialdehycle as dispersed medium. The products were characterized by IR, SEM, TEM, UV/Vis. The results show that the microspheres are spherical in shape with smooth surfaces. The diameter of the microspheres is in the rang from 5 to 10μm, The content of drug in microspheres is 6.2% and of Fe3O4 is 19%. The drug encapsulation efficiency is 61.4%, the quantity of drug released from microspheres in 5 hours is 74.4%. The microspheres have good properties of drug sustain releasing. |
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| Keywords: | gelatin norfloxacin magnetic microsphere controlled release |
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