| 2-氰基-4'-甲基联苯的合成 |
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| 引用本文： | 常瑜,相会明,宋广慧,翟红.2-氰基-4''''-甲基联苯的合成[J].化工生产与技术,2007,14(4):31-33. |
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| 作者姓名： | 常瑜 相会明 宋广慧 翟红 |
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| 作者单位： | 太原理工大学化学工程与技术学院 太原030024 |
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| 摘 要： | 以邻氯苯腈和格氏试剂为原料,过渡金属化合物为催化剂,N-甲基吡咯烷酮作溶剂,一步合成得到2-氰基-4'-甲基联苯,通过单因素实验,考察了催化剂种类、溶剂种类、溶剂用量、滴加速度对反应的影响.实验结果表明,该反应的最佳条件为:168 mmol氯化镍作催化剂,210 mL N-甲基吡咯烷酮作溶剂,滴加时间为2 h;在最佳合成条件下,2-氰基-4'-甲基联苯的收率可达89.0%,纯度可达98.8%.
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| 关 键 词： | 2-氰基-4'-甲基联苯 过渡金属 催化剂 格氏试剂 |
| 文章编号： | 1006-6829(2007)04-0031-03 |
| 修稿时间： | 2007年7月17日 |
Synthesis of 2-Cyano-4'-methylbiphenyl |
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| Chang Yu,Xiang Huiming,Song Guanghui,Zhai Hong.Synthesis of 2-Cyano-4''''-methylbiphenyl[J].Chemical Production and Technology,2007,14(4):31-33. |
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| Authors: | Chang Yu Xiang Huiming Song Guanghui Zhai Hong |
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| Abstract: | Chlorobenzonitrile and Grignard reagents are used as raw materials, and transition metal complex as a catalyst, 1-methyl-2-pyrrolidinone as a solvent to synthesize 2-cyano-4'-methylbiphenyl in one step. Catalyst kinds, solvent kinds, effects of solvent kinds and dripping addition on the reaction are reviewed through a single factor experiment. Results of the experiment show the best conditions of this reaction is:168 mol Nickel chloride as a catalyst, 210 mL 1-methyl-2-pyrrolidinone, addition time is 2 h; under the best synthesis conditions, 2-cyano-4'-methylbiphenyl has a yield as high as 89.0% and purity 98.8%. |
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| Keywords: | 2-cyano-4'-methylbiphenyl transition metal catalyst synthesis intermediate |
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