A method for functional magnetic resonance imaging of olfaction |
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Authors: | N Sobel V Prabhakaran JE Desmond GH Glover EV Sullivan JD Gabrieli |
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Affiliation: | Department of Neuroscience, Stanford University, CA 94305, USA. nsobel@leland/stanford.edu |
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Abstract: | A method for generating olfactory stimuli for humans within a functional magnetic resonance imaging (fMRI) experimental design is described. The system incorporates a nasal-mask in which the change from odorant to no-odorant conditions occurs in less than 500 ms and is not accompanied by visual, auditory, tactile, or thermal cues. The mask provides an ordorant-free environment following prolonged ordorant presence. Specific imaging parameters that are conducive to the study of the human olfactory system are described. In a pilot study performed using these methods, the specific patterns of activation observed converged with published experimental and clinical findings. |
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