| 3-膦酸二甲酯基-2-甲基-1,1-二甲氧基丙烷的制备 |
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| 引用本文： | 陈钧,潘伯安,曹启学,李良军,周志奎,姚礼高,吴青华. 3-膦酸二甲酯基-2-甲基-1,1-二甲氧基丙烷的制备[J]. 浙江化工, 2010, 41(2): 9-10 |
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| 作者姓名： | 陈钧 潘伯安 曹启学 李良军 周志奎 姚礼高 吴青华 |
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| 作者单位： | 1. 浙江国邦药业有限公司,浙江,上虞,312369
2. 浙江医药股份有限公司新昌制药厂,浙江,新昌,312500 |
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| 摘 要： | 2-甲基烯丙醇催化氧化得到2-甲基烯丙醛,然后再与氯化氢和甲醇低温缩合加成得到3-氯-2-甲基-1,1-二甲氧基丙烷,此中间体与亚膦酸三甲酯进行Arbuzov反应得到3-膦酸二甲酯基-2-甲基-1,1-二甲氧基丙烷,产物是类胡萝卜素的重要中间体。产物含量95.5%,收率41.7%。
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| 关 键 词： | 3-膦酸二甲酯基-2-甲基-1 ,1-二甲氧基丙烷 3-氯-2-甲基-1, 1-二甲氧基丙烷 2-甲基烯丙醛 Arbuzov反应 2-甲基烯丙醇 |
Synthesis of 3-Dimethyl phosphonate-2-methyl-1,1-dimethoxyl-propane |
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| CHEN Jun,PAN Bo-an,CHAO Qi-xue,LI Liang-jun,ZHOU Zhi-kui,YAO Li-gao,WU Qing-hua. Synthesis of 3-Dimethyl phosphonate-2-methyl-1,1-dimethoxyl-propane[J]. Zhejiang Chemical Industry, 2010, 41(2): 9-10 |
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| Authors: | CHEN Jun PAN Bo-an CHAO Qi-xue LI Liang-jun ZHOU Zhi-kui YAO Li-gao WU Qing-hua |
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| Affiliation: | 1. Zhejiang Guobang Pharmaceutical Co., Ltd., Shaoxing 312369, China; 2. Zhejiang Medicine Co.,Ltd., Xinehang Pharmaceutical Factory, Xinehang 312500, China) |
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| Abstract: | 2-Methyl-propenal is prepared by oxidation of 2-methyl-propenol on presence of catalyst, then convert to 3-chloro-2-methyl-1,1-dimethoxyl-propane by condensation and addition reaction with HC1 and methnol at low temperature, which undergo Arbuzov reaction to obtain 3-Dimethyl phosphonate-2-methyl-1,1- dimethoxyl-propane, which is an important intermediate of carotenoid.Content is 95.5%, total yield is 41.7%. |
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| Keywords: | 3 -dimethyl phosphonate -2 -methyl - ,1 1 -dimethoxyl -propane 3 -chloro -2 -methyl - 1,1 - dimethoxyl-propane 2-methyl-propenal arbuzov reaction 2-methyl-propenol |
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