Three-dimensional structure of protein C inhibitor predicted from structure of {alpha}1-antitrypsin with computer graphics期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Three-dimensional structure of protein C inhibitor predicted from structure of {alpha}1-antitrypsin with computer graphics

Authors:	Toma, K. Yamamoto, S. Deyashiki, Y. Suzuki, K.

Affiliation:	¹Bio-Science Laboratory, Life Science Research Laboratories, Asahi Chemical Industry Fuji, Shizuoka 416 ²Department of Laboratory Medicine, Mie University School of Medicine Tsu, Mie 514, Japan Computer Science Department, Life Science Research Laboratories, Asahi Chemical Industry Fuji, Shizuoka 416

Abstract:	The three-dimensional structure of a proteolytically modifiedprotein C inhibitor, a member of the serine protease inhibitorsuperfamily, was constructed with computer graphics based onits amino acid sequence homology with that of the modified ${alpha}$ 1-antitrypsinwhose structure had been elucidated by X-ray crystallography.The intact form of protein C inhibitor was predicted with an ${alpha}$ -carbon model based on its hydrophilicity and hydrogen bondpattern. Furthermore, a model of its interaction with activatedprotein C was constructed based on the structure of the complexbetween trypsin and its inhibitor, which had been determinedby X-ray crystallography.

Keywords:	computer graphics/ model building/ protein C/ protein C inhibitor/ three-dimensional structure
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