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| 氧氯化法制备5-氯-8-羟基喹啉的研究 | |
| 引用本文： | 张珍明,王丽萍,李树安,葛洪玉. 氧氯化法制备5-氯-8-羟基喹啉的研究[J]. 化工时刊, 2010, 24(5): 27-29. DOI: 10.3969/j.issn.1002-154X.2010.05.008 |
| 作者姓名： | 张珍明 王丽萍 李树安 葛洪玉 |
| 作者单位： | 1. 中国矿业大学环境与测绘学院,江苏,徐州,221116;淮海工学院,化学工程学院,江苏,连云港,222005 2. 中国矿业大学环境与测绘学院,江苏,徐州,221116 3. 淮海工学院,化学工程学院,江苏,连云港,222005 |
| 基金项目： | 江苏省海洋资源开发研究院基金，江苏省教育厅"青蓝工程"优秀学科带头人项目，江苏省连云港市科技局项目，淮海工学院绿色精品课程建设项目 |
| 摘 要： | 研究了8-羟基喹啉、过氧化氢为主要原料通过氧氯化方法制备医药和农药的重要中间体5-氯-8-羟基喹啉的工艺条件。8-羟基喹啉、过氧化氢和30%盐酸投料比为1∶1.05∶16.7,在10~15℃下把过氧化氢滴加到8-羟基喹啉和盐酸的混和物中反应2 h,抽滤分离出5-氯-8-羟基喹啉盐酸盐,用盐酸萃取,用28%氨水中和至pH6.7得到5-氯-8-羟基喹啉,质量分数大于99%,收率为82.4%。研究了投料比、反应温度和时间对5-氯-8-羟基喹啉收率的影响。 |
| 关 键 词： | 5-氯-8-羟基喹啉 8-羟基喹啉 氧氯化反应 过氧化氢 |
Study on the Preparation of 5-chloro-8-hydroxyquinoline with Oxidative Chlorination |
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| Zhang Zhenming,Wang Liping,Li Shuan,Ge Hongyu. Study on the Preparation of 5-chloro-8-hydroxyquinoline with Oxidative Chlorination[J]. Chemical Industry Times, 2010, 24(5): 27-29. DOI: 10.3969/j.issn.1002-154X.2010.05.008 | |
| Authors: | Zhang Zhenming Wang Liping Li Shuan Ge Hongyu |
| Affiliation: | 1.College of Environment and Surveying,China Mining University,Jiangsu Suzhou 221116;2.Dept.of Chemical Engineering,Huaihai Institute of Technology,Jiangsu Lianyungang 222005) |
| Abstract: | 5-chloro-8-hydroxyquinoline,an important intermediate used for medicine and agriculture,was prepared by oxidative chlorination of 8-hydroxyquinoline with H2O2.The optimam conditions were as follows： molar ratio of 8-hydroxyquinoline：H2O2∶30%HCl=1∶5∶1.1,and H2O2 added dropwise to the mixture of 8-hydroxyquinoline and hydrochloric acid at 10~15℃ for 4 h.After working up,5-chloro-8-hydroxyquinoline was obtained in 82.1% yield and 98.7% purity.The effects of ratio of raw materials,reaction temperature and time on the yield of 5-chloro-8-hydroxyquinoline were also investigated. |
| Keywords: | 5-chloro-8-hydroxyquinoline 8-hydroxyquinoline oxidative chlorination hydrogen peroxide |
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