| 4,8-E-法呢基乙酸香叶酯的合成 |
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| 引用本文： | 陈文章,李永,朱高峰,李谦,汤磊. 4,8-E-法呢基乙酸香叶酯的合成[J]. 广州化工, 2014, 0(17): 56-57 |
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| 作者姓名： | 陈文章 李永 朱高峰 李谦 汤磊 |
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| 作者单位： | 贵阳医学院药学院,贵州 贵阳,550004 |
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| 基金项目： | 贵州省科技厅贵阳医学院联合基金资助项目(黔科合 LG 字[2012]011号)；贵阳医学院青年基金资助项目(院基金合同字第2012018号)；贵州省高等学校创新能力提升计划黔教合协同创新字[2013]04。 |
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| 摘 要： | 以橙花叔醇、原乙酸三甲酯为原料、丁酸为催化剂、在130-150℃条件下,经酯交换、重排反应、得到法呢基乙酸甲酯顺反异构体,后在氢氧化钾的条件下水解、蒸干得法呢基乙酸钾盐顺反异构体、再以乙酸乙酯为溶剂结晶分离、酸化、得到4,8-E-法呢基乙酸,与香叶醇缩合得到4,8-E-法呢基乙酸香叶酯。该法操作简单,条件温和、总收率为27.6%。
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| 关 键 词： | 4,8-E-法呢基乙酸香叶酯 橙花叔醇 香叶醇 合成 |
The Synthesis of 4,8-E-farnesyl Geranyl Acetate |
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| CHEN Wen-zhang,LI Yong,ZHU Gao-feng,LI Qian,TANG Lei. The Synthesis of 4,8-E-farnesyl Geranyl Acetate[J]. GuangZhou Chemical Industry and Technology, 2014, 0(17): 56-57 |
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| Authors: | CHEN Wen-zhang LI Yong ZHU Gao-feng LI Qian TANG Lei |
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| Affiliation: | CHEN Wen-zhang;LI Yong;ZHU Gao-feng;LI Qian;TANG Lei;School of Pharmacy,Guiyang Medical University; |
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| Abstract: | Nerolidol and trimethyl orthoacetate was used as starting material to give farnesylacetic acid by esterification,rearrangement reaction between 130 - 150 ℃ in the presence of butyric acid. Farnesyl acetate potassium cis and trans isomers was obtained via hydrolysis reaction in the condition of potassium hydroxide. Following by crystallization separation in ethyl acetate and acidification,condensation with geraniol the title compund 4,8- E- farnesyl geranyl acetate was achieved. This method was simple,the reaction conditions were mild,and the total yield was 27. 6%. |
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| Keywords: | 4,8-E-farnesyl geranyl acetate nerolidol geraniol synthesis |
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