A cross-sectional study on the relationship between depression and left ventricular hypertrophy |
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Authors: | Y Takemura S Kikuchi H Takagi Y Inaba K Nakagawa |
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Affiliation: | Department of Radiation Biology, St Bartholomew's and the Royal London School of Medicine and Dentistry, UK. k.r.trott@mds.qmw.ac.uk |
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Abstract: | PURPOSE: The relationship between different forms of persistent radiation damage in irradiated cells was investigated in order to identify a common underlying mechanism. MATERIAL AND METHODS: V-79 Chinese hamster cells were irradiated with different doses of X-rays, neutrons and alpha-particles. In the progeny of surviving cells, up to 4 weeks after irradiation, delayed reproductive death, delayed micronuclei, delayed appearance of dicentric chromosomes and delayed apoptosis were investigated in parallel. RESULTS: A similar dose-response relationship was found for all endpoints, with a steep rise at low doses to a plateau at doses > 3 Gy. The target for inducing genomic instability by alpha-particles is larger than the nucleus. All chromosomes are equally involved in delayed breakage reunion events. CONCLUSION: The results indicate that non-lethal radiation damage to an extranuclear target leads to a persistent increase in clastogenic activity in the surviving irradiated cells. |
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