| 敌磺钠及其代谢物在茭白中的残留分析及细胞毒性 |
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| 引用本文： | 张锦芳,刘焱,张阳,杨星,刘彬,徐玥,徐文平.敌磺钠及其代谢物在茭白中的残留分析及细胞毒性[J].农药,2021(2):128-130,138. |
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| 作者姓名： | 张锦芳 刘焱 张阳 杨星 刘彬 徐玥 徐文平 |
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| 作者单位： | 华东理工大学药学院;国化低碳技术工程中心;上海南方农药研究中心;上海市青浦区蔬菜技术推广站;中国化工经济技术发展中心 |
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| 基金项目： | 上海市青浦区科技发展基金项目(青科发2019-17)。 |
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| 摘 要： | 目的]测定药后茭白中敌磺钠的残留量、敌磺钠及其代谢物对2种人体细胞HepG2和HEK-293的毒性,为该药物在茭白上的使用安全性提供技术资料.方法]茭白在药后1、3、5 d采样,用QuEChERS方法前处理,GC-MS方法测定其代谢产物N,N-二甲基苯胺在茭白食用部分的残留.利用MTT法测定敌磺钠及其代谢产物N,N...
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| 关 键 词： | 敌磺钠 N N-二甲基苯胺 茭白 残留 细胞毒性 |
The Residue Analysis of Fenaminosulf and Its Metabolite in Zizania latifolia and Its Cytotoxicity Assays |
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| ZHANG Jin-fang,LIU Yan,ZHANG Yang,YANG Xing,LIU Bin,XU Yue,XU Wen-ping.The Residue Analysis of Fenaminosulf and Its Metabolite in Zizania latifolia and Its Cytotoxicity Assays[J].Pesticides,2021(2):128-130,138. |
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| Authors: | ZHANG Jin-fang LIU Yan ZHANG Yang YANG Xing LIU Bin XU Yue XU Wen-ping |
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| Affiliation: | (College o f Pharmacy,East China University of Science and Technology,Shanghai 200237,China;National Chemical Low Carbon Technology and Engineering Center,Kunshan 215313,Jangsu,China;Shanghai Southern Pesticide Research Center,Shanghai 201702,China;Shanghai Qingpu District Vegetable Technology Promotion Station,Shanghai 201700,China;S.China National Chemical Economic and Technical Development Center,Beijing 100723,China) |
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| Abstract: | Aims] This study aims to detect the residue of fenaminosulf and its metabolite N,N-dimethylaniline in Zizania latifolia and the cytotoxicity to two kind of human cells HepG2 and HEK-293, to provide technical information on the safety of the pesticide in the use of Z. latifolia. Methods] Z. latifolia samples were taken on the first, third and fifth days after treatment, by QuEChERS method to process samples and GC-MS to detect the residue of its metabolites N,N-dimethylaniline in Z. latifolia. The MTT assay was used to determine the 24 h cytotoxicity on the cell HepG2 and HEK-293. Results] The residue of N,N-dimethylaniline on the first day after treatment was 147.08 μg/kg, no residue was detected on the third day and the fifth day;the IC50 of HepG2 and HEK-293 treated with fenaminosulf are166.77, 309.76 mg/L, the IC50 of HepG2 and HEK-293 treated with N,N-dimethylaniline are 788.19, 956.72 mg/L.Conclusions] The residue of fenaminosulf and its metabolite N,N-dimethylaniline in Z. latifolia is low, and the cytotoxicity to cells HepG2 and HEK-293 is low. It provides scientific basis for study on safety of fenaminosulf. |
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| Keywords: | fenaminosulf N N-dimethylaniline Zizania latifolia residue cytotoxicity |
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