大豆异黄酮加钙复合剂对卵巢切除大鼠骨密度和骨钙含量的影响

利用卵巢切除大鼠模型 ,研究大豆异黄酮 +钙复合剂对骨密度和骨钙含量的影响。卵巢切除大鼠分为 3个剂量组 ,分别灌胃给予 6 7mg kgBW 大豆异黄酮 +16 7mg kgBW 钙 (低剂量组 )、13 3mg kgBW 大豆异黄酮 +33 3mg kg BW 钙 (中剂量组 )和 4 0 0mg kg BW 大豆异黄酮 +10 0 0mg kgBW钙 (高剂量组 ) ,同时设阴性对照组和假手术组。 12周后测定股骨骨密度 (MBD)、骨矿含量(BMC)和骨钙含量。结果发现假手术组、中剂量组和高剂量组大鼠股骨干骺端BMD、BMC和股骨钙含量显著高于阴性对照组 (P <0 0 5 ) ,表明大豆异黄酮 +钙复合剂能增加卵巢切除大鼠的骨密度 ,对雌激素缺乏所诱发的骨丢失具有抑制作用。

Effects of the combination of soy isoflavones and calcium on bone density and calcium content in ovariectomized rats

Ovariectomized (OVX) rat models were applied to conduct the effects of combination of soy isoflavones (SIF) and calcium (Ca) on bone mineral density (BMD) and bone calcium content in this study. The OVX rats were allocated to five groups:OVX control group, sham group and 3 treatment groups. Rats in 3 treatment groups were treated by gavage using 6^7 mg/kg BW of SIF plus 16^7 mg/kg BW of Ca, 13^3 mg/kg BW of SIF plus 33^3 mg/kg BW of Ca and 40^0 mg/kg BW of SIF plus 100^0 mg/kg BW of Ca, respectively. Femoral BMD, bone mineral content (BMC) and calcium content were measured after 12-week administration. The results showed that rats in sham group and treated with 40^0 mg/kg BW of SIF plus 100^0 mg/kg BW of Ca had significantly higher BMC, BMD in metaphisis and femoral calcium content than those in OVX control group (P<0.05). It demonstrated that the combination of SIF and Ca could increase BMD and bone calcium content in OVX rats, and inhibite the bone loss induced by estrogen deficiency effect on estrogen deficiency-induced bone loss.